Derivatization Reagents: Silylation Reagents

• Replaces active hydrogen, reducing polarity and making the compounds more volatile.
• Increases stability of derivatives.

Silylation is the most widely used derivatization procedure for sample analysis by GC. In silylation, an active hydrogen is replaced by an alkylsilyl group such as trimethylsilyl (TMS) or tert-butyldimethylsilyl (tert-BDMS). Silyl derivatives are more volatile, less polar, and more thermally stable. As a result, GC separation is improved and detection is enhanced.
Both TMS and tert-BDMS reagents are suitable for a wide variety of compounds and can be used for many GC applications. Note that silylation reagents are generally moisture sensitive and must be sealed to prevent deactivation.

	Description	CAS #	qty.	Cat.#
	MSTFA (N-methyl-N-trimethylsilytrifluoroacetamide)	24589-78-4	10-pk. (10x1g)	35600
	MSTFA (N-methyl-N-trimethylsilytrifluoroacetamide)	24589-78-4	25g vial	35601
	MSTFA w/1% TMCS (N-methyl-N-trimethylsilytrifluoroacetamide w/1% trimethylchlorosilane)	24589-78-4	10-pk. (10x1g)	35602
	MSTFA w/1% TMCS (N-methyl-N-trimethylsilytrifluoroacetamide w/1% trimethylchlorosilane)	24589-78-4	25g vial	35603
	BSTFA (N,O-bis[trimethylsilyl]trifluoroacetamide)	25561-30-2	10-pk. (10x1g)	35604
	BSTFA (N,O-bis[trimethylsilyl]trifluoroacetamide)	25561-30-2	25g vial	35605
	BSTFA w/1% TMCS (N,O-bis[trimethylsilyltrifluoroacetamide] w/1% trimethylchlorosilane)	25561-30-2	10-pk. (10x1g)	35606
	BSTFA w/1% TMCS (N,O-bis[trimethylsilyltrifluoroacetamide] w/1% trimethylchlorosilane)	25561-30-2	25g vial	35607
	MTBSTFA w/1% TBDMCS (N-methyl-N[tert-butyldimethylsilyl trifluoroacetamide] w/1% tert-butyldimethylchlorosilane)	77377-52-7	10-pk. (10x1g)	35608
	MTBSTFA w/1% TBDMCS (N-methyl-N[tert-butyldimethylsilyl trifluoroacetamide] w/1% tert-butyldimethylchlorosilane)	77377-52-7	25g vial	35610
	TMCS (trimethylchlorosilane)	75-77-4	10-pk. (10x1g)	35611
	TMCS (trimethylchlorosilane)	75-77-4	25g vial	35612